Software peaq

Unattended operation of the instrument after sample loading frees operator time. This complete system requires no additional accessories, reagents or consumables. Functional structures formed by proteins and other macromolecules often undergo temperature-induced conformational changes, such as unfolding.

These changes result in the absorption of heat as a result of the redistribution of non-covalent bonds within the molecule. Differential Scanning Calorimeters measure this heat uptake very precisely. The thermal core of the MicroCal PEAQ-DSC system contains a sample cell containing the sample of interest and a reference cell containing a matched buffer solution , both of which are housed within an insulating jacket.

These two cells are always maintained at the same temperature, and during a measurement, they are heated at a constant scan rate. Since protein unfolding is an endothermic event, it is observed as a positive displacement in the thermogram.

Webinar: Value of DSC in characterization and optimization of protein stability as compared to other thermal stability assays. Liposomes are used as model membrane systems and as potential drug delivery systems. Download brochure. Request a quote Request a demo Contact sales. Features and benefits Differential Scanning Calorimetry DSC is a powerful analytical tool for characterizing the thermal stability of proteins and other biomolecules.

Key Features Gold standard stability-indicating technique requiring minimal assay development Direct and label-free measurement of biomolecular native-state stability in solution Standard well plate format for high capacity and easy loading, with thermostatically-controlled storage of up to 6 plates Fully integrated autosampler enables unattended analysis of up to 50 samples per day Automated cell filling and cell cleaning functions permit unattended operation Measurement of very tight binding constants, up to 10 20 M -1 Powerful MicroCal PEAQ-DSC software minimizes typical data analysis time and includes: PEAQ-Compliance: The system is available with Malvern Access Controller MAC to limit access to user-defined SOPs and data analysis features.

Provides new algorithms to detect even subtle peaks and shoulders, facilitating the automatic, non-subjective identification of multiple transitions, such as those seen in multi-domain proteins PEAQ-Compare: For the quantitative comparison of DSC traces for comparability studies, ideal for batch-to-batch and biosimilarity studies Network-ready: email updates sent during the analysis to keep you informed of assay progress The MicroCal PEAQ-DSC is also available as a manual system without the autosampler.

How it works Functional structures formed by proteins and other macromolecules often undergo temperature-induced conformational changes, such as unfolding. Support Protect your investment and ensure optimized performance at all times with Malvern Panalytical's service plans.

Help Desk Telephone and email support. Operators who take responsibility for your call and ensure your query is answered. Training User training events Software downloads A simple mechanism for receiving updates and new features Malvern Panalytical's service options- choose the right plan for you: Malvern Panalytical Platinum Plan For laboratories where maximizing instrument up-time is critical to its daily performance.

Malvern Panalytical Gold Plan Enhance your laboratory productivity by maintaining instrument efficiency. Malvern Panalytical Bronze Visit For laboratories looking to optimize instrument performance, regular preventative maintenance is essential. Webinar: Solve stability problems in preformulation and process development using DSC Application note: Using Differential Scanning Calorimetry to accelerate liquid formulation development for protein biopharmaceuticals Biosimilarity and Biocomparabilty The highly reproducible nature of the MicroCal PEAQ-DSC instruments and the ability of the technique to detect even changes to a single amino acid in a protein have been the core drivers behind the use of DSC data in submissions for approval for biosimilar drugs.

Whitepaper: Characterization of biopharmaceutical stability with Differential Scanning Calorimetry: Biosimilarity and batch-to-batch comparability Characterization of Antibody Drug Conjugates and Vaccines DSC, DLS and other biophysical technique can be used to study the stability of Antibody Drug Candidates and the effects of antibody drug ratios on their stability and propensity to aggregate.

D — GlaxoSmithKline. Website feedback Site map Cookie settings. Terms relating to software downloads. If you download software from this site, use of the software is subject to the licence terms in the Software Licence Agreement. Downloading software assumes you understand and agree to the terms of the software licensing agreement. The materials and services provided at this site are provided "as is" without any warranties of any kind.